The Fed’s rate decision is dropping today, and a drop in rates is what we expect. The market is shifting fast. Some DeFi altcoins are ready for some explosive upside as liquidity rotates. The money printer is turning on once again…..
Today, we’ll reveal three altcoins with massive potential:
- one tokenized assets leader partnering with TradFi giants
- one high-speed perpetuals DEX gaining adoption
- and a DeFi OG preparing a Bitcoin layer-2 move.
Stick around! These could be your top gainers after today’s rate announcement.
Ondo Finance ($ONDO)
I know we sound like a broken record talking about Ondo so often. But their market position is unique and tough to copy. Ondo Finance has grown into one of DeFi’s strongest tokenization platforms. It ranks inside the top 100 with a market cap around $1.6B.
Tokenized versions of public securities like
- U.S. Treasuries
- Bonds
- and now equities is their model.
As markets digest today’s rate move, demand for real-world asset yield could spike. This favors Ondo’s narrative. Only days ago, Ondo partnered with Ledger. Now you have direct access to tokenized U.S. stocks and ETFs through its platform. This is a first-of-its-kind development. Now, Wall Street and DeFi investors come together in one streamlined user experience. Lower rates mean people have to invest to put their money to work. And partnerships like this add powerful momentum to Ondo’s adoption curve.
Ondo is improving secondary market access for its $OUSG token, too. And that means institutions can get in and out of crypto and move assets on-chain with ease. These moves are critical as traditional players step into tokenized markets post-rate announcement.
We’re proud to share that Ondo Finance’s OUSG fund is the sole anchor and largest investor in Fidelity’s new tokenized fund, Fidelity Digital Interest Token (FDIT).
Fidelity’s entry marks another major milestone in the institutional embrace of tokenization. We’re encouraged to… pic.twitter.com/s4vuARj4Tf
— Ondo Finance (@OndoFinance) September 9, 2025
The ecosystem continues to expand: Ondo’s total value locked surged above $1.6 billion. This is a sign that investor appetite for yield-bearing RWAs is strong.
Treasury inflows grew 18% quarter-over-quarter. Meanwhile, secondary market trading volumes increased on platforms like Coinbase and Bitget. These metrics show strong conviction even before today’s policy update.
Technical analysis shows us $ONDO has held support near $0.90, with resistance at $1.25 for most of 2025.
Lower rates will drive more demand for RWAs. A breakout above resistance could drive short-term upside. Price would then challenge the recent high of $2.05 in December.
Hyperliquid ($HYPE)
Hyperliquid ($HYPE) is a big deal when it comes to trading perpetuals on a DEX. It has grown fast with a market cap crossing $700M and increasing volumes. Its on-chain matching engine enables high-frequency trading with minimal latency. This sets it apart from competitors. In other words, it mimics TradFi exchanges in speed, scalability, and security.
In a post-rate-hike environment, leverage demand spikes. Perpetual DEXs like Hyperliquid stand to capture significant inflows. Cheaper money to borrow means more leveraged trades.
Recently, Hyperliquid integrated Circle’s USDC expansion. This ensures deep stablecoin liquidity across its trading pairs. Stablecoins improve capital efficiency and builds trust for institutions and retail traders alike. And now Hyperliquid has the best one available for users.
Circle x Hyperliquid expansion.
Circle is proud to bring trusted liquidity, interoperability, and support for builders into one of the most innovative platforms in crypto.
Read more: https://t.co/2hbfNIHFn9 pic.twitter.com/21y6cyAvW6
— Circle (@circle) September 16, 2025
Another big headline is Hyperliquid’s launch of USDH, its native stablecoin. It happened after winning a competitive bid to expand into the stablecoin sector. The stablecoin test phase has already gone live. And expectations are high that it will attract liquidity providers in droves.
Over the past week, the community engaged with teams’ proposals for the USDH ticker for a Hyperliquid-first, Hyperliquid-aligned, compliant, and natively minted USD stablecoin. While USDH is no more than a reserved ticker at the protocol level, it has come to represent a…
— Hyper Foundation (@HyperFND) September 11, 2025
Hyperliquid’s daily trading volume has surged past $500M for its $HYPE token. With TVL climbing to over $660M according to DeFiLlama.
Its rising open interest levels mirror increasing trader confidence. This is especially true when rates drive volatility across crypto assets. Open interest is another way to say active trades in the market.
Price-wise, $HYPE has support near $37 and resistance around $55. A clean breakout above $ could open the path to $88, according to analysts. It would reflect growing trader adoption and ease of use with more stablecoin access.
Uniswap ($UNI)
Uniswap remains the DeFi kingpin with a market cap of almost $6B. It dominates decentralized liquidity provision.
It’s got huge brand power. Uniswap has broad integrations and retail presence, too. This gives it an edge when macro shifts spark trading surges.
As rates drop, which is what we expect, users often rush to DeFi blue-chips. And UNI stands as a natural starting point in that search.
The biggest news: Uniswap Labs is preparing to integrate Bitcoin on a new layer-2 network. This move will expand liquidity beyond Ethereum. $BTC can trade on Uniswap on its own. This unlocks massive user inflows from Bitcoin holders. Thanks to an integration with BOB, Building on Bitcoin.
Uniswap is becoming THE place to swap between Layer 2 solutions, as well. This is an important function for interoperability improvements. For the moment, we must deal with fragmented liquidity on different chains. And as we do, Uniswap benefits.
L2 volume on the Uniswap Protocol is *this* close to setting a new yearly all-time high pic.twitter.com/lvZGTQPEe7
— Uniswap Labs 🦄 (@Uniswap) September 16, 2025
Ecosystem-wise, Uniswap commands over $5B in TVL. Its daily trading volumes average $4B per day over the last 30 days.
Its liquidity provider community is still one of the most engaged in DeFi. And there are still some great rates you can earn on Uniswap’s Liquidity Pools.
Technical Analysis tells us $UNI trades between $6.50 support and $12.15 resistance. With catalysts like Bitcoin layer-2 integration, analysts expect $UNI could retest $12 in the coming weeks. That’s if price momentum builds post-rate announcement.
What do you think of these three altcoins? Does it include your favorite pick of altcoins? If not, let me know in the comments which altcoins you favor. Do join us in our social media on X and Discord.
Disclaimer
The information discussed by Altcoin Buzz is not financial advice. This is for educational, entertainment and informational purposes only. Any information or strategies are thoughts and opinions relevant to accepted levels of risk tolerance of the writer/reviewers, and their risk tolerance may be different from yours.
We are not responsible for any losses that you may incur as a result of any investments directly or indirectly related to the information provided. Bitcoin and other cryptocurrencies are high-risk investments, so please do your due diligence.
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